# Question 2: Using appropriate statistical method(s) investigate whether patients who had a history of being treated with Drug-X on a regular basis have significantly different systolic blood pressure (SBP)

Data Description (CVD-Data): Consider a study where twelve baseline variables (e.g., age, gender, weight, BMI, etc.) among others were collected from each of the 1429 participants. Out of the 1429 participants, 952 had a history of being treated with Drug-X on a regular basis. The objective of the study was to investigate whether Drug-X was protective for various risk factors of cerebrovascular vascular disease (CVD). The participants were then followed for 5 years and their mortality status was recorded. The short and long names of the variables are given in Table 1. Note: Baseline Variable is collected at the beginning of a study.

Table 1: Variable description for the study

 Variable Description Statistical Code (if any) AGE Age N/A GENDER Gender 0 for female and 1 for male WEIGHT Weight N/A BMI Body mass index 0 for <25; 1 for 25 to <30; 2 for 30 to <35 and 3 for 35 and above SBP Systolic blood pressure N/A DBP Diastolic blood pressure N/A CHL Cholesterol level N/A SMOKE Smoking status 0 for never smoked and 1 for smoked Drug-X Drug 'X' treated 0 for no and 1 for yes PAD Peripheral arterial disease 0 for no and 1 for yes STROKE Stroke 0 for no and 1 for yes DEATH Follow-up mortality status 0 for no and 1 for yes

Question 1 [5 marks]: Consider that an investigator aims to assess whether `Drug-X. was protective for 'mortality' in the study sample. Evaluate the investigator's aim by presenting the related data on an appropriate graph (Hint: no additional summary statistics or significance test required for answering this question).

Question 2 [35 marks]: Using appropriate statistical method(s) investigate whether patients who had a history of being treated with Drug-X on a regular basis have significantly different systolic blood pressure (SBP), diastolic blood pressure (DBP) and cholesterol level (CHL) compared to patients without Drug-X treated.

Please fill up the following table from the above analysis results.

 Variable                       Summary statistics p-value 95% CI (where appropriate) Yes Drug-X No Drug-X Systolic blood pressure SBP Diastolic blood pressure DBP Cholesterol level (CHL)

Question 3 120 marks]: Using appropriate statistical methods evaluate the significance of difference of CHL and SBP between the BMI categories.

Question 4 120 marks]: Using appropriate statistical methods compare patients' SBP and DBP by STROKE status. Hint: Statistical significance test required.

Question 5 115 marks]: In a clinical trial, 35 subjects were treated with a new drug to show the efficacy of the drug in reducing diastolic blood pressure (DBP). Their blood pressure was observed before the treatment and after 10 weeks of the treatment (see the DBP-data on the Moodle site). Using appropriate statistical method(s) evaluate whether the drug is significantly effective.

Question 6 [5 marks]: State the learning outcomes of Modules 4-7 and describe how this assignment questions are aligned with these learning outcomes (maximum of 150 words, this will be excluded from the total word count of this assessment).

Important information

• The 2500 word limit does not include the content page, tables, graphs or appendix.
• Your report must be formatted in A4 size (210 x 297 mm), with Times New Roman, size 12 font.
• Name your file with your file name and the assessment number: Iastnamc-firstname­
• Your report must not be longer than 25 If you have any more than that, only the first 25 pages will be assessed.
• All important analysis output must be added as an appendix, with table/graph number and a proper title.
• You must combine all the information into a SINGLE Word (.docx) file, as you will only be able to make one submission to the assessment dropbox. For full information about submission, see the "Submission details and feedback".
• You must not copy and paste information from the internet. If you do use internet information, please put it in your own words. References may not be required, but if you do use them, you must cite all of your sources using the Vancouver referencing
• This assessment is worth 30%. It will be marked as a percentage of 100.

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